Recombinant Human Angiotensinogen/AGT protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Angiotensinogen protein Asp25-Ala476 (Accession# P01019) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 183 |
| 蛋白编号 | P01019 |
| 预测分子量 | 75.8 kDa |
| SDS-PAGE | 75-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Angiotensinogen(AGT), a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development.
参考文献:
1. Hong Lu. et al. (2016). Hypertens Res.39(7):492-500. 2. Tanvir Kahlon. et al.(2022). JACC Heart Fail.10(10):699-713. 3. M Caulfield. et al. (1996). Hypertension. 28(6):1123-5. 4. L Morgan. et al. (1996). Int J Biochem Cell Biol. 28(11):1211-22.
