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Recombinant Human ACAN protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

C-rFc

生物活性

未测试

Cat no : Eg2994

Print datasheet

Synonyms

ACAN, AGC1, AGCAN, aggrecan, Aggrecan 1

验证数据展示

  • Purity of Recombinant Human ACAN was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ACAN was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human ACAN protein Val20-Arg675 (Accession# P16112-1) with a rabbit IgG Fc tag at the C-terminus
基因ID 176
蛋白编号 P16112-1
预测分子量 98.6 kDa
SDS-PAGE 110-130 kDa, reducing (R) condition
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ACAN, or Aggrecan, is a key component of the extracellular matrix in cartilaginous tissues. Acan is present in cartilage, intervertebral disc, brain, heart, and aorta (PMID: 35385326). Its core protein contains three glubular domains and two glycosaminoglycan-attachment domains. These domains play various roles to maintain cartilage structure and function.

参考文献:

1. Watanabe H. (2022). Am J Physiol Cell Physiol. 322(5):C967-C976.
2. Watanabe H. et al. (1998). J Biochem. 124(4):687-93.