Recombinant Human ABCB1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 |
Not tested |
来源 | HEK293-derived Human ABCB1 protein Met68-Tyr116 (Accession# P08183-1) with a rabbit IgG Fc tag at the N-terminus |
基因ID | 5243 |
蛋白编号 | P08183-1 |
预测分子量 | 32.9 kDa |
SDS-PAGE | 35-45 kDa, reducing (R) condition |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ABCB1 (also known as P-gp/ P-glycoprotein, MDR1/multidrug-resistance 1) is a plasma membrane protein first discovered in multidrug resistant tumor cells. ABCB1 can extrude a large number of medically relevant compounds from cells and causes drug resistance. ABCB1 is expressed in a variety of human cancers as well as normal tissues including brain, and placenta. Overexpression of ABCB1 correlates with a negative prognosis in several types of cancer.
参考文献:
1. Skinner, Katie T et al. Cancers vol. 15,17 4236. 24 Aug. 2023. 2. Abd El-Aziz, Yomna S et al. Bioscience reports vol. 41,2 (2021): BSR20204092.