Recombinant Human ABCB1 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2366

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Synonyms

ATP-binding cassette sub-family B member 1, ATP-dependent translocase ABCB1, EC:7.6.2.1, EC:7.6.2.2, MDR1



产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性
Not tested
来源 HEK293-derived Human ABCB1 protein Met68-Tyr116 (Accession# P08183-1) with a rabbit IgG Fc tag at the N-terminus
基因ID 5243
蛋白编号 P08183-1
预测分子量 32.9 kDa
SDS-PAGE 35-45 kDa, reducing (R) condition
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ABCB1 (also known as P-gp/ P-glycoprotein, MDR1/multidrug-resistance 1) is a plasma membrane protein first discovered in multidrug resistant tumor cells. ABCB1 can extrude a large number of medically relevant compounds from cells and causes drug resistance. ABCB1 is expressed in a variety of human cancers as well as normal tissues including brain, and placenta. Overexpression of ABCB1 correlates with a negative prognosis in several types of cancer.

参考文献:

1. Skinner, Katie T et al. Cancers vol. 15,17 4236. 24 Aug. 2023. 2. Abd El-Aziz, Yomna S et al. Bioscience reports vol. 41,2 (2021): BSR20204092.