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验证数据展示

  • WB analysis using 67168-1-Ig (same clone as 67168-1-PBS)

    WB analysis using 67168-1-Ig (same clone as 67168-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67168-1-Ig (HUS1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67168-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate cancer using 67168-1-Ig (same clone as 67168-1-PBS)

    IHC staining of human prostate cancer using 67168-1-Ig (same clone as 67168-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 67168-1-Ig (HUS1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67168-1-PBS in a different storage buffer formulation.

HUS1 Monoclonal antibody, PBS Only

HUS1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 67168-1-PBS

产品说明书

CloneNo. 1E8E9

宿主/亚型

Mouse / IgG1

种属反应性

Human

应用

WB, IHC, Indirect ELISA

别名

Checkpoint protein HUS1, hHUS1, HUS1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

67168-1-PBS targets HUS1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human
免疫原

CatNo: Ag28527

Product name: Recombinant human HUS1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-280 aa of BC007013

Sequence: MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 HUS1 checkpoint homolog (S. pombe)
别名 Checkpoint protein HUS1, hHUS1, HUS1
计算分子量 32 kDa
观测分子量 32 kDa
GenBank蛋白编号BC007013
基因名称 HUS1
Gene ID (NCBI) 3364
RRIDAB_2882464
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDO60921
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Hus1 belongs to the Rad family, form a heterotrimeric clamp with Rad1and Rad9 that acts as a putative sensor for DNA damage. This complex plays an apical role in the DNA damage response, loss of a functional complex affects many downstream checkpoint pathways [PMID: 11340080]. It is also a key complex involved in the activation of the ATR pathway. 9-1-1 forms a ring-shaped heterotrimer, resembling the homotrimeric sliding clamp, proliferating cell nuclear antigen (PCNA) [PMID: 19535328].

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