HPSE2 Polyclonal antibody

HPSE2 Polyclonal Antibody for WB, ELISA
Cat No. 21128-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, ELISA and More (1)

heparanase 2, Hpa2, HPR2, Inactive heparanase-2

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格价格库存


经过测试的应用

Positive WB detected inL02 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21128-1-AP targets HPSE2 in WB, IF, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
文献引用应用WB, IF
经测试反应性 human
文献引用反应性human
免疫原 HPSE2 fusion protein Ag15526 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 heparanase 2
别名 heparanase 2, Hpa2, HPR2, Inactive heparanase-2
计算分子量 592 aa, 67 kDa
观测分子量 54 kDa, 66 kDa
GenBank蛋白编号BC112356
基因名称 HPSE2
Gene ID (NCBI) 60495
RRIDAB_10733344
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8WWQ2
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

HPSE2 (heparanase 2) is a homolog of HPSE (heparanase 1). HPSE is an endo-β-glucuronidase that cleaves heparan sulfate proteoglycans (HSPGs), which are important components of the extracellular matrix and basement membranes. HPSE2, however, lacks intrinsic heparan sulfate-degrading activity. Instead, it binds to heparan sulfate with higher affinity than HPSE, thereby competing with HPSE for heparan sulfate binding and inhibiting HPSE's enzymatic activity. This competitive inhibition makes HPSE2 a crucial regulator of heparan sulfate metabolism.

实验方案

Product Specific Protocols
WB protocol for HPSE2 antibody 21128-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB,IF

Viruses

Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate

Authors - James Hopkins
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