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验证数据展示

  • IF Staining of A549 using 14336-1-AP (same clone as 14336-1-PBS)

    IF Staining of A549 using 14336-1-AP (same clone as 14336-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A549 cells using 14336-1-AP (HLX antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • WB analysis of human placenta using 14336-1-AP (same clone as 14336-1-PBS)

    WB analysis of human placenta using 14336-1-AP (same clone as 14336-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 14336-1-AP (HLX antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • IHC staining of human endometrial cancer using 14336-1-AP (same clone as 14336-1-PBS)

    IHC staining of human endometrial cancer using 14336-1-AP (same clone as 14336-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human endometrial cancer using 14336-1-AP (HLX antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • IHC staining of human endometrial cancer using 14336-1-AP (same clone as 14336-1-PBS)

    IHC staining of human endometrial cancer using 14336-1-AP (same clone as 14336-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human endometrial cancer using 14336-1-AP (HLX antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

HLX Polyclonal antibody, PBS Only

HLX Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 14336-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14336-1-PBS targets HLX in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag5627

Product name: Recombinant human HLX protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 134-488 aa of BC033808

Sequence: QQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 H2.0-like homeobox
别名
计算分子量 51 kDa
观测分子量 51 kDa
GenBank蛋白编号BC033808
基因名称 HLX
Gene ID (NCBI) 3142
RRIDAB_2232971
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ14774
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

In immune system, Hlx is a Th1-special transcription factor that interacts specifically with T-bet, and synergistically they promote IFN-γ expression when co-expressed. It can down-regulate the IL-4 receptor expression in naive CD4+ T cells [PMID:14688316]. Over expression of Hlx contributes ot the aberrant expression of IFN-γ in normal CD4+ T cells during the differentiation under Th2-polarizing conditions. In addition, Hlx is a negative regulator of IFN-γ production in NK cells and its inhibitory function is achieved at least in part through the proteasomal degradation of STAT4 [PMID:16424184].

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