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验证数据展示

  • WB analysis of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

    WB analysis of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 22788-1-AP (HIC2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22788-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

    IP experiment of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

    IP result of anti-HIC2 (IP:22788-1-AP, 4ug; Detection:22788-1-AP 1:300) with Jurkat cells lysate 2400ug. This data was developed using the same antibody clone with 22788-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

HIC2 Polyclonal antibody, PBS Only

HIC2 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 22788-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IP, Indirect ELISA

别名

Hic 2, Hic 3, HIC1-related gene on chromosome 22 protein, Hic-2, Hic-3

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

22788-1-PBS targets HIC2 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag18789

Product name: Recombinant human HIC2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 161-430 aa of BC094787

Sequence: RSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 hypermethylated in cancer 2
别名 Hic 2, Hic 3, HIC1-related gene on chromosome 22 protein, Hic-2, Hic-3
计算分子量 615 aa, 66 kDa
观测分子量 66 kDa
GenBank蛋白编号BC094787
基因名称 HIC2
Gene ID (NCBI) 23119
RRIDAB_2879169
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96JB3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HIC2 (hypermethylated in cancer 2) is a transcription factor related to the tumour suppressor HIC1, required for normal cardiac development and lost in distal variants of 22q11 Deletion Syndrome (PMID: 29061339). HIC2 is also a POK family protein, and the amino acid sequence of its BTB/POZ and zinc-finger domains are similar to those of HIC1(PMID: 31127867). Studies have shown that HIC2 plays a role in suppressing fetal genes for normal development of the heart and circulatory system, in embryogenesis (PMID: 24748541).

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