验证数据展示
产品信息
17954-1-PBS targets HFE in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag12448 Product name: Recombinant human HFE protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 29-295 aa of BC074721 Sequence: SLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQEGSESSSLPGKVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWE 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | hemochromatosis |
| 别名 | hemochromatosis, HFE1, HH, HLA H, HLAH |
| 计算分子量 | 345 aa, 40 kDa |
| 观测分子量 | 45-58 kDa |
| GenBank蛋白编号 | BC074721 |
| 基因名称 | HFE |
| Gene ID (NCBI) | 3077 |
| RRID | AB_10596779 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q30201 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
HFE is an important iron metabolism regulatory protein, which regulates the production of hepcidin through interactions with other proteins such as transferrin receptor 1 (TfR1) and TfR2. HFE is the most common pathogenic gene for hereditary hemochromatosis, which is a hereditary disease of iron accumulation in multiple organs caused by mutations in genes regulating iron metabolism.
