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验证数据展示

  • WB analysis of HeLa using 85627-1-RR (same clone as 85627-1-PBS)

    WB analysis of HeLa using 85627-1-RR (same clone as 85627-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 85627-1-RR (HERPUD1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85627-1-PBS in a different storage buffer formulation.

  • WB analysis of LNCaP using 85627-1-RR (same clone as 85627-1-PBS)

    WB analysis of LNCaP using 85627-1-RR (same clone as 85627-1-PBS)

    LNCaP cells were subjected to SDS PAGE followed by western blot with 85627-1-RR (HERPUD1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85627-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 85627-1-RR (same clone as 85627-1-PBS)

    IHC staining of human lung cancer using 85627-1-RR (same clone as 85627-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 85627-1-RR (HERPUD1 antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85627-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 85627-1-RR (same clone as 85627-1-PBS)

    IHC staining of human lung cancer using 85627-1-RR (same clone as 85627-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 85627-1-RR (HERPUD1 antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85627-1-PBS in a different storage buffer formulation.

HERPUD1 Recombinant monoclonal antibody, PBS Only

HERPUD1 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 85627-1-PBS

产品说明书

CloneNo. 243054E4

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

HERP, Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, KIAA0025, Methyl methanesulfonate, MIF1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

85627-1-PBS targets HERPUD1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag34891

Product name: Recombinant human HERPUD1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 94-391 aa of BC008320

Sequence: MPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN*

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
别名 HERP, Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, KIAA0025, Methyl methanesulfonate, MIF1
计算分子量 44 kDa
观测分子量 54 kDa
GenBank蛋白编号BC008320
基因名称 HERPUD1
Gene ID (NCBI) 9709
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ15011
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1), also called HERP or MIF1, is component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. HERP is strongly induced by ER stress but rapidly degraded by proteasome. HERP interacts with members of the ubiquilin family, which function as a shuttle factor to deliver ubiquitinated substrates to the proteasome for degradation. HERP is present in activated microglia in senile plaques in the brain of patients with Alzheimer disease, and there is evidence suggesting HERP increase nigro-striatal dopaminergic activity and is able to improve symptoms in patients with Parkinson's disease, levodopa-related dyskinesias and Tardive dyskinesia. MW of HERP is 54 kDa (PMID: 23620059).

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