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验证数据展示

  • WB analysis using 86879-3-RR (same clone as 86879-3-PBS)

    WB analysis using 86879-3-RR (same clone as 86879-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86879-3-RR (HBZ antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86879-3-PBS in a different storage buffer formulation.

  • IF Staining of K-562 using 86879-3-RR (same clone as 86879-3-PBS)

    IF Staining of K-562 using 86879-3-RR (same clone as 86879-3-PBS)

    Immunofluorescent analysis of (4% PFA) fixed K-562 cells using HBZ antibody (86879-3-RR, Clone: 251873A7 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86879-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86879-3-RR

    Affinity and Kinetic Characterization of 86879-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86879-3-RR against Human HBZ were performed. The affinity constant is below 1 pM.

HBZ Recombinant monoclonal antibody, PBS Only

HBZ Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86879-3-PBS

产品说明书

CloneNo. 251873A7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

HBAZ, HBZ2, Hemoglobin subunit zeta, Hemoglobin zeta chain, hemoglobin, mu

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86879-3-PBS targets HBZ in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag11061

Product name: Recombinant human HBZ protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-142 aa of BC027892

Sequence: MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHGSKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTAEAHAAWDKFLSVVSSVLTEKYR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 hemoglobin, zeta
别名 HBAZ, HBZ2, Hemoglobin subunit zeta, Hemoglobin zeta chain, hemoglobin, mu
计算分子量 142 aa, 16 kDa
观测分子量16 kDa
GenBank蛋白编号BC027892
基因名称 HBZ
Gene ID (NCBI) 3050
RRIDAB_3745181
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP02008
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HBZ, also named as Zeta-globin and HBAZ, belongs to the globin family. HBZ is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac. HBZ was first identified as an antisense viral protein that associated with cAMP-response element binding protein-2 (CREB-2) in HTLV-1-infected cells. HBZ is the only viral gene that is expressed in all ATL cases (PMID: 22787458). ShRNA repression of HBZ expression in established HTLV-1-transformed cell lines and newly immortalized T-lymphocytes also significantly suppressed T-lymphocyte proliferation (PMID: 19650892, 16917009).

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