验证数据展示
发表文章中的应用
| IHC | See 2 publications below |
| IF | See 1 publications below |
产品信息
26420-1-AP targets HAVCR1 in IHC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | IHC |
| 经测试反应性 | human |
| 文献引用反应性 | mouse |
| 免疫原 |
CatNo: Ag23888 Product name: Recombinant human HAVCR1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 21-87 aa of BC013325 Sequence: SVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRD 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | hepatitis A virus cellular receptor 1 |
| 别名 | CD365, HAVCR, HAVCR 1, HAVCR1, Kidney injury molecule 1, KIM 1, KIM1, T cell membrane protein 1, TIM, TIM 1, TIM1, TIMD 1, TIMD1 |
| 计算分子量 | 359 aa, 39 kDa |
| GenBank蛋白编号 | BC013325 |
| 基因名称 | HAVCR1 |
| Gene ID (NCBI) | 26762 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q96D42 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Hepatitis A virus cellular receptor 1 (HAVCR1, also known as TIM-1, KIM-1 or CD365) is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. HAVCR1 acts as a membrane receptor for hepatitis A virus (HHAV) (PMID: 9658108; 8861957). HAVCR1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). HAVCR1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that HAVCR1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).
发表文章
| Species | Application | Title |
|---|---|---|
Drug Deliv Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury. | ||
