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验证数据展示

  • WB analysis using 85122-4-RR (same clone as 85122-4-PBS)

    WB analysis using 85122-4-RR (same clone as 85122-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85122-4-RR (GYS2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85122-4-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 85122-4-RR (same clone as 85122-4-PBS)

    IHC staining of mouse liver using 85122-4-RR (same clone as 85122-4-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide (positive control) and mouse skeletal muscle tissue slide (Negative control) using 85122-4-RR (GYS2 antibody) at dilution of 1:50000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85122-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85122-4-RR

    Affinity and Kinetic Characterization of 85122-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85122-4-RR against Human GYS2 were performed. The affinity constant is 3.11 nM.

GYS2 Recombinant monoclonal antibody, PBS Only

GYS2 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 85122-4-PBS

产品说明书

CloneNo. 242595F10

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

242595F10, EC:2.4.1.11, Glycogen synthase 2, glycogen synthase 2 (liver)

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

85122-4-PBS targets GYS2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag18012

Product name: Recombinant human GYS2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 604-703 aa of BC126310

Sequence: YYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 glycogen synthase 2 (liver)
别名 242595F10, EC:2.4.1.11, Glycogen synthase 2, glycogen synthase 2 (liver)
计算分子量 703 aa, 81 kDa
观测分子量 81 kDa
GenBank蛋白编号BC126310
基因名称 GYS2
Gene ID (NCBI) 2998
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP54840
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GYS2 (Glycogen Synthase 2) is a key enzyme involved in the synthesis of glycogen in the liver. It catalyzes the addition of glucose molecules to the growing glycogen chain, playing a crucial role in maintaining glucose homeostasis. GYS2 is essential for liver glycogen synthesis, which acts as a critical energy reserve for maintaining blood glucose levels, especially during fasting or prolonged exercise. Impairment of GYS2 function can lead to glycogen storage disease type 0 (GSD-0), characterized by hypoglycemia and liver glycogen deficiency. The GYS2 is highest expressed in the liver, and its expression in liver was significantly higher than other tissues. (PMID:39150597; PMID:37574425)

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