验证数据展示
经过测试的应用
| Positive WB detected in | mouse brain tissue, rat brain tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
87729-1-RR targets GRM5 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | glutamate receptor, metabotropic 5 |
| 别名 | GPRC1E, mGlu5, MGLUR5 |
| 计算分子量 | 132 kDa |
| 观测分子量 | 120 kDa |
| GenBank蛋白编号 | NM_000842 |
| 基因名称 | GRM5 |
| Gene ID (NCBI) | 2915 |
| RRID | AB_3745722 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P41594 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
GRM5 (mGluR5) is a group I class C GPCR that couples to Gq/PLCβ signaling to regulate postsynaptic glutamatergic transmission, calcium signaling, and synaptic plasticity. Highly enriched in cortical, hippocampal, and striatal neurons, GRM5 is a key modulator of learning, memory, excitability, and neurobehavioral circuit function. Dysregulation of GRM5 signaling has been implicated in fragile X syndrome, autism-related disorders, neuropsychiatric disease, chronic pain, and neurodegeneration, making it a major target in CNS drug discovery.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for GRM5 antibody 87729-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
