验证数据展示
经过测试的应用
| Positive IHC detected in | mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| IF | See 1 publications below |
产品信息
19955-1-AP targets mGluR1 in IHC, IF-P, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | IHC, IF-P, ELISA Application Description |
| 文献引用应用 | IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | glutamate receptor, metabotropic 1 |
| 别名 | GRM1, MGLUR1A, mGlu1, GRM1A, GPRC1A |
| 计算分子量 | 132 kDa |
| GenBank蛋白编号 | NM_000838 |
| 基因名称 | GRM1 |
| Gene ID (NCBI) | 2911 |
| RRID | AB_10638312 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q13255 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
GRM1, also named as GPRC1A and MGLUR1, belongs to the G-protein coupled receptor 3 family. GRM1 is a receptor for glutamate. The activity of GRM1 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It may participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. The antibody can recognize isoform1 and isoform2 of GRM1.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for mGluR1 antibody 19955-1-AP | Download protocol |
| IHC protocol for mGluR1 antibody 19955-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Int J Biol Sci Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications. | ||
Clin Cancer Res Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells. | ||
J Transl Med ALDH1L1 reverses CD8(+) T cell exhaustion in the oral squamous cell carcinoma microenvironment by reprogramming L-glutamate metabolism. | ||
Brain Commun M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology. |
