验证数据展示
产品信息
20338-1-AP targets GPNMB in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag14124 Product name: Recombinant human GPNMB protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 22-181 aa of BC011595 Sequence: AKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLG 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | glycoprotein (transmembrane) nmb |
| 别名 | GPNMB, HGFIN, Transmembrane glycoprotein NMB |
| 计算分子量 | 64 kDa |
| 观测分子量 | 68 kDa |
| GenBank蛋白编号 | BC011595 |
| 基因名称 | GPNMB |
| Gene ID (NCBI) | 10457 |
| RRID | AB_10667459 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q14956 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
GPNMB also known as HGFIN, osteoactivin, and DC-HIL, is a type I membrane glycoprotein involved in various biological processes, including inflammation, invasion and metastasis of malignant tumors, cell differentiation, and tissue regeneration. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB acts as an osteogenic factor that stimulates osteoblast differentiation in vivo and in vitro.
发表文章
| Species | Application | Title |
|---|---|---|
J Am Heart Assoc Global Characteristics and Dynamics of Single Immune Cells After Myocardial Infarction | ||
Inflammation Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease. | ||
J Pathol GPNMB expression identifies TSC1/2/mTOR-associated and MiT family translocation-driven renal neoplasms | ||
Mol Cell Biochem Downregulation of glycoprotein non-metastatic melanoma protein B prevents high glucose-induced angiogenesis in diabetic retinopathy
| ||
J Cell Physiol Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer. |
