验证数据展示
产品信息
33606-1-PBS targets GLCE in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag35424 Product name: Recombinant human GLCE protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 29-200 aa of BC160046 Sequence: NKCSSDKAIQFPRRSSSGFRVDGFEKRAAASESNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGLKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | glucuronic acid epimerase |
| 别名 | D-glucuronyl C5-epimerase, EC:5.1.3.17, Heparan sulfate C5-epimerase, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase |
| 观测分子量 | 70 kDa |
| GenBank蛋白编号 | BC160046 |
| 基因名称 | GLCE |
| Gene ID (NCBI) | 26035 |
| RRID | AB_3743028 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | O94923 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
GLCE encodes the C5-epimerase responsible for converting glucuronic acid to iduronic acid during heparan sulfate biosynthesis. Localized in the Golgi apparatus, it indirectly regulates growth factor signaling, angiogenesis, and cell-cell interactions through structural diversification of glycosaminoglycan chains. Dysregulation of GLCE has been associated with cancer progression and developmental abnormalities, highlighting its role at the interface of glycobiology and disease. (PMID: 24499487)
