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验证数据展示

  • WB analysis of MCF-7 using 16209-1-AP (same clone as 16209-1-PBS)

    WB analysis of MCF-7 using 16209-1-AP (same clone as 16209-1-PBS)

    MCF7 cells were subjected to SDS PAGE followed by western blot with 16209-1-AP (GGCX antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16209-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 16209-1-AP (same clone as 16209-1-PBS)

    IHC staining of human liver using 16209-1-AP (same clone as 16209-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver using 16209-1-AP (GGCX antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 16209-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 16209-1-AP (same clone as 16209-1-PBS)

    IHC staining of human liver using 16209-1-AP (same clone as 16209-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver using 16209-1-AP (GGCX antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 16209-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse liver using 16209-1-AP (same clone as 16209-1-PBS)

    IP experiment of mouse liver using 16209-1-AP (same clone as 16209-1-PBS)

    IP result of anti-GGCX (IP:16209-1-AP, 4ug; Detection:16209-1-AP 1:2000) with mouse liver tissue lysate 4000ug. This data was developed using the same antibody clone with 16209-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

GGCX Polyclonal antibody, PBS Only

GGCX Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 16209-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

16209-1-PBS targets GGCX in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag9185

Product name: Recombinant human GGCX protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 383-758 aa of BC013979

Sequence: LTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 gamma-glutamyl carboxylase
别名
计算分子量 758 aa, 88 kDa
观测分子量 88 kDa
GenBank蛋白编号BC013979
基因名称 GGCX
Gene ID (NCBI) 2677
RRIDAB_2110874
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP38435
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GGCX(Gamma-glutamyl carboxylase) is also named as GC and belongs to the vitamin K-dependent gamma-carboxylase family. This 94 kDa (including all modifications, such as the five N-linked glycosylations), is a 5-pass transmembrane protein and a key regulator of blood coagulation(PMID:20518534). It mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Defects in GGCX are a cause of combined deficiency of vitamin K-dependent clotting factors type 1 (VKCFD1) and pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD)(PMID:9845520;17110937).

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