验证数据展示
产品信息
16415-1-PBS targets GALNT12 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag9571 Product name: Recombinant human GALNT12 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-272 aa of BC013945 Sequence: MAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) |
| 别名 | EC:2.4.1.41, GalNAc T12, GalNAc-T12, Polypeptide N-acetylgalactosaminyltransferase 12, pp GaNTase 12 |
| 计算分子量 | 581 aa, 67 kDa |
| 观测分子量 | 67 kDa |
| GenBank蛋白编号 | BC013945 |
| 基因名称 | GALNT12 |
| Gene ID (NCBI) | 79695 |
| RRID | AB_3741886 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q8IXK2 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Polypeptide N‑acetylgalactosaminyl transferase 12 (GALNT12) belongs to the uridine diphosphate N‑acetylgalactosamine gene family, which is involved in numerous biological processes of diseases, such as tumor progression. GALNT12 is highly expressed in the digestive tract and it is frequently downregulated in colorectal cancer (CRC) (PMID: 29095867). Genetic knockdown (KD) and knockout (KO) of GALNT12 in U87 MG, a representative GBM cell line with high GALNT12 expression, confirmed that GALNT12 deficiency leads to decreased cell proliferation, migration and invasion (PMID: 35461073).
