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验证数据展示

  • WB analysis of mouse skeletal muscle using 12979-1-AP (same clone as 12979-1-PBS)

    WB analysis of mouse skeletal muscle using 12979-1-AP (same clone as 12979-1-PBS)

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12979-1-AP (GABRA4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12979-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse skeletal muscle using 12979-1-AP (same clone as 12979-1-PBS)

    IP experiment of mouse skeletal muscle using 12979-1-AP (same clone as 12979-1-PBS)

    IP result of anti-GABRA4 (IP:12979-1-AP, 4ug; Detection:12979-1-AP 1:500) with mouse skeletal muscle tissue lysate 2200ug. This data was developed using the same antibody clone with 12979-1-PBS in a different storage buffer formulation.

  • WB analysis using 12979-1-AP (same clone as 12979-1-PBS)

    WB analysis using 12979-1-AP (same clone as 12979-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12979-1-AP (GABRA4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12979-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 12979-1-AP (same clone as 12979-1-PBS)

    IHC staining of mouse brain using 12979-1-AP (same clone as 12979-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 12979-1-AP (GABRA4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12979-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 12979-1-AP (same clone as 12979-1-PBS)

    IHC staining of mouse brain using 12979-1-AP (same clone as 12979-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 12979-1-AP (GABRA4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12979-1-PBS in a different storage buffer formulation.

GABRA4 Polyclonal antibody, PBS Only

GABRA4 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 12979-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

GABA A Receptor alpha 4, GABA(A) receptor subunit alpha-4, GABAA Receptor alpha 4, GABAAR subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-4

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12979-1-PBS targets GABRA4 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag3600

Product name: Recombinant human GABRA4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 338-554 aa of BC035055

Sequence: AAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 gamma-aminobutyric acid (GABA) A receptor, alpha 4
别名 GABA A Receptor alpha 4, GABA(A) receptor subunit alpha-4, GABAA Receptor alpha 4, GABAAR subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-4
计算分子量 554 aa, 62 kDa
观测分子量 62-70 kDa
GenBank蛋白编号BC035055
基因名称 GABRA4
Gene ID (NCBI) 2557
RRIDAB_2108996
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP48169
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABRA4, encoding the extrasynaptically located α4‐subunit of the GABAA receptor, is involved in the etiology of autism. (PMID: 32028044, 32033586)

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