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验证数据展示

  • IP experiment of mouse brain using 34058-1-AP (same clone as 34058-1-PBS)

    IP experiment of mouse brain using 34058-1-AP (same clone as 34058-1-PBS)

    IP result of anti-G2E3 (IP:34058-1-AP, 4ug; Detection:34058-1-AP 1:500) with mouse brain tissue lysate 1960 ug. This data was developed using the same antibody clone with 34058-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 34058-1-AP (same clone as 34058-1-PBS)

    IHC staining of human kidney using 34058-1-AP (same clone as 34058-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 34058-1-AP (G2E3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 34058-1-PBS in a different storage buffer formulation.

G2E3 Polyclonal antibody, PBS Only

G2E3 Polyclonal Antibody for IHC, IP, Indirect ELISA
Cat No. 34058-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, IP, Indirect ELISA

别名

KIAA1333, PHF7B

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

34058-1-PBS targets G2E3 in IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag40477

Product name: Recombinant human G2E3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 231-340 aa of BC000973

Sequence: ERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 G2/M-phase specific E3 ubiquitin ligase
别名 KIAA1333, PHF7B
计算分子量 706 aa, 81 kDa
观测分子量80 kDa
GenBank蛋白编号BC000973
基因名称 G2E3
Gene ID (NCBI) 55632
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ7L622
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

G2/M-phase specific E3 ubiquitin protein ligase (G2E3) is a cell cycle-regulated E3 ubiquitin ligase that plays a critical role in controlling the G2/M transition. It functions by targeting specific substrates for proteasomal degradation during late G2 and M phases, thereby ensuring proper cell cycle progression. G2E3 contains a RING finger domain, characteristic of E3 ubiquitin ligases, and its expression is tightly regulated in a cell cycle-dependent manner, peaking during G2/M phases. Research has implicated G2E3 in various cellular processes, including DNA damage response and mitotic regulation (PMID: 17239372; PMID: 18511420; PMID: 41068090).

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