验证数据展示
产品信息
67039-1-PBS targets Flightless I in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
| 经测试应用 | WB, IHC, Indirect ELISA Application Description |
| 经测试反应性 | Human, Mouse, Rat |
| 免疫原 | Flightless I fusion protein Ag26865 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | flightless I homolog (Drosophila) |
| 别名 | FLI, Fli1, Flightless I, FLII, FLIL, Protein flightless 1 homolog |
| 计算分子量 | 1269 aa, 145 kDa |
| 观测分子量 | 145-150 kDa |
| GenBank蛋白编号 | BC025300 |
| 基因名称 | Flightless I |
| Gene ID (NCBI) | 2314 |
| RRID | AB_2882353 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q13045 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Flightless I (FliI) is the most evolutionarily conserved member of the gelsolin superfamily of proteins which are key regulators of actin filament assembly and turnover. FliI comprises an N-terminal leucine-rich repeat (LRR) domain which is not present in other gelsolin family members, and the LRR domain may enable interactions between FliI and other molecules involved in signal transduction, thereby spatially integrating signaling and actin remodeling functions. This protein was originally found in Drosophila and participates in the embryonic development, while mammalian FliI protein was involved in the regulation of wound repair,skin barrier development. Studies recently demonstrated that FliI protein associated with colorectal cancer, hepatocellular and prostate cancer (PMID:30091651; 28498392).
