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Filaggrin Polyclonal antibody, PBS Only

Filaggrin Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 26931-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, Indirect ELISA

FLG

缓冲液配方: 
偶联物:  Unconjugated
规格价格库存


产品信息

26931-1-PBS targets Filaggrin in IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag25389

Product name: Recombinant human Filaggrin protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-102 aa of NM_002016

Sequence: MRKENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTEN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 filaggrin
别名 FLG
计算分子量 435 kDa
GenBank蛋白编号NM_002016
基因名称 FLG
Gene ID (NCBI) 2312
RRIDAB_3742205
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP20930
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Profilaggrin is a major protein component of the keratohyalin granules of mammalian epidermis. It is initially expressed as a large polyprotein precursor, which is subsequently proteolytically processed into individual functional filaggrin molecules. The free filaggrin binds to keratin intermediate filaments, causing their aggregation into macrofibrils in which the intermediate filaments are aligned in tightly packed parallel arrays. Mutations in Filaggrin are associated with Ichthyosis vulgaris and Dermatitis atopic 2.(PMID: 19386895, 16550169)

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