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验证数据展示

  • WB analysis of human plasma using 11867-1-AP (same clone as 11867-1-PBS)

    WB analysis of human plasma using 11867-1-AP (same clone as 11867-1-PBS)

    human plasma were subjected to SDS PAGE followed by western blot with 11867-1-AP (Ficolin-3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11867-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 11867-1-AP (same clone as 11867-1-PBS)

    IF Staining of HepG2 using 11867-1-AP (same clone as 11867-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using Ficolin 3 antibody (11867-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 11867-1-PBS in a different storage buffer formulation.

Ficolin 3 Polyclonal antibody, PBS Only

Ficolin 3 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 11867-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

Hakata antigen, HAKA1, FCNH, FCN3, Collagen/fibrinogen domain-containing protein 3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

11867-1-PBS targets Ficolin 3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2449

Product name: Recombinant human FCN3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 20-288 aa of BC020731

Sequence: CLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
别名 Hakata antigen, HAKA1, FCNH, FCN3, Collagen/fibrinogen domain-containing protein 3
计算分子量 33 kDa
观测分子量 32 kDa
GenBank蛋白编号BC020731
基因名称 Ficolin-3
Gene ID (NCBI) 8547
RRIDAB_2104432
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO75636
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Ficolins are a group of oligomeric lectins with subunits consisting of both collagen-like and fibrinogen-like domains (PMID: 20375620). They are innate pattern recognition receptors and play integral roles within the innate immune response. In humans, there are three ficolins termed M-, L-, and H-ficolin (also referred to as ficolin-1, -2, and -3) whereas rodents only possess ficolin-A and -B, which are the orthologues of human L- and M-ficolin, respectively (PMID: 30868077). Ficolin-3 (Hakata antigen or H-ficolin) was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus (PMID: 1859827). It has been shown to have a calcium-independent lectin activity. Ficolin-3 is associated with MASPs and sMAP, and which activates the lectin pathway (PMID: 11907111). Ficolin-3 shows affinity for GalNAc, GlcNAc, D-fucose and galactose (PMID: 30868077).

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