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Fibrinogen Alpha Chain Polyclonal antibody

Fibrinogen Alpha Chain Polyclonal Antibody for WB, IHC, ELISA
Cat No. 20645-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, ELISA and More (2)

FGA, Fib2, Fibrinopeptide A

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inmouse liver tissue
Positive IHC detected inhuman liver cancer tissue, human colon tissue, human lung cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:3000
Immunohistochemistry (IHC)IHC : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

20645-1-AP targets Fibrinogen Alpha Chain in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, ELISA Application Description
文献引用应用WB, IHC, IF, IP
经测试反应性 human, mouse
文献引用反应性human, mouse
免疫原 Fibrinogen Alpha Chain fusion protein Ag9567 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 fibrinogen alpha chain
别名 FGA, Fib2, Fibrinopeptide A
计算分子量 866 aa, 95 kDa
观测分子量 60 kDa
GenBank蛋白编号BC020764
基因名称 Fibrinogen Alpha Chain
Gene ID (NCBI) 2243
RRIDAB_2878715
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP02671
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGA is the alpha chain of fibrinogen. During conversion of fibrinogen to fibrin, fibrinopeptide A is cleaved from FGA by thrombin.

实验方案

Product Specific Protocols
WB protocol for Fibrinogen Alpha Chain antibody 20645-1-APDownload protocol
IHC protocol for Fibrinogen Alpha Chain antibody 20645-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseIF

Nat Commun

Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies.

Authors - Di-Wei Zheng
humanWB,IP

Free Radic Biol Med

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.

Authors - Yuanzhen Ma
humanWB

Aging (Albany NY)

Serum proteomic predicts effectiveness and reveals potential biomarkers for complications in liver transplant patients.

Authors - Wenjing Wang
mouseWB

J Cell Mol Med

Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice

Authors - Guillaume Postic
mouse

J Thromb Haemost

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) cross-linking via tissue transglutaminase.

Authors - L G Poole
humanIF

Phytomedicine

Geniposide alleviates VEGF-induced angiogenesis by inhibiting VEGFR2/PKC/ERK1/2-mediated SphK1 translocation.

Authors - Yan Wang
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