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验证数据展示

  • WB analysis using 87432-2-RR (same clone as 87432-2-PBS)

    WB analysis using 87432-2-RR (same clone as 87432-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87432-2-RR (FBL antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87432-2-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 87432-2-RR (same clone as 87432-2-PBS)

    IF Staining of HepG2 using 87432-2-RR (same clone as 87432-2-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using Fibrillarin antibody (87432-2-RR, Clone: 252802F8 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 87432-2-PBS in a different storage buffer formulation.

Fibrillarin Recombinant monoclonal antibody, PBS Only

Fibrillarin Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 87432-2-PBS

产品说明书

CloneNo. 252802F8

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IF/ICC, Indirect ELISA

别名

FBL, EC:2.1.1.-, FIB, FIB1, FLRN

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy FBL Ready-To-Use IHC Kit. FBL primary antibody included.

产品信息

87432-2-PBS targets Fibrillarin in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag8841

Product name: Recombinant human FBL protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-321 aa of BC019260

Sequence: MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 fibrillarin
别名 FBL, EC:2.1.1.-, FIB, FIB1, FLRN
计算分子量 321 aa, 34 kDa
观测分子量 34 kDa
GenBank蛋白编号BC019260
基因名称 FBL
Gene ID (NCBI) 2091
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP22087
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Fibrillarin (Fbl) is an essential nucleolar protein that plays an essential role in ribosome biogenesis and more particularly in the methylation of ribosomal RNAs and rDNA histones. FBL is highly expressed in various cancers and correlates with poor survival outcomes in cancer patients,such as hepatocellular carcinoma(PMID: 33376525). Knockdown of FBL sensitizes tumor cells and xenografts to DNA crosslinking agents, and leads to homologous recombination-mediated DNA repair defects(PMID: 37489617).

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