验证数据展示
发表文章中的应用
WB | See 1 publications below |
IF | See 1 publications below |
产品信息
51035-1-AP targets Fabp4 in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | ELISA Application Description |
文献引用应用 | WB, IF |
经测试反应性 | human, mouse, rat |
文献引用反应性 | mouse, pig |
免疫原 | Fabp4 fusion protein Ag0712 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | fatty acid binding protein 4, adipocyte |
别名 | 422/aP2, ALBP/Ap2, Ap2, Fabp4, Lbpl |
计算分子量 | 15 kDa |
观测分子量 | 15 kDa |
GenBank蛋白编号 | BC054426 |
基因名称 | Fabp4 |
Gene ID (NCBI) | 11770 |
RRID | AB_670380 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P04117 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Fatty acid binding protein (FABP) 4 is a member of the FABP family which abundantly expressed, fatty acid carrier proteins. FABPs are capable of binding a variety of hydrophobic molecules such as long-chain fatty acids and are important for their uptake and intracellular trafficking. It was first identified as an adipocyte-specific protein, important for the maintenance of lipid and glucose metabolism. It is also detected in macrophages, where it participates in regulating inflammation and cholesterol trafficking via NFκB and PPAR. In more recent studies, FABP4 has been found in a variety of endothelial cells, where it has been identified as a target of VEGF and a regulator of cell proliferation and possibly angiogenesis. Pathologically, FABP4 has been associated with the development of metabolic syndrome, diabetes and cancer and vulnerability of atherosclerotic plaques. FABP4 has been identified as a novel prognostic factor for both adverse cardiovascular events and breast cancer.
实验方案
Product Specific Protocols | |
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WB protocol for Fabp4 antibody 51035-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
发表文章
Species | Application | Title |
---|---|---|
J Anim Sci Antimicrobial peptide KR-32 alleviates Escherichia coli K88-induced fatty acid malabsorption by improving expression of FATP4. |