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验证数据展示

  • WB analysis using 32075-1-AP (same clone as 32075-1-PBS)

    WB analysis using 32075-1-AP (same clone as 32075-1-PBS)

    Various lysates were subjected to Tris-Acetate gel system followed by western blot with 32075-1-AP (FRY antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32075-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 32075-1-AP (same clone as 32075-1-PBS)

    IHC staining of human pancreas cancer using 32075-1-AP (same clone as 32075-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 32075-1-AP (FRY antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32075-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 32075-1-AP (same clone as 32075-1-PBS)

    IHC staining of human pancreas cancer using 32075-1-AP (same clone as 32075-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 32075-1-AP (FRY antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32075-1-PBS in a different storage buffer formulation.

  • IHC staining of human urothelial carcinoma using 32075-1-AP (same clone as 32075-1-PBS)

    IHC staining of human urothelial carcinoma using 32075-1-AP (same clone as 32075-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue slide using 32075-1-AP (FRY antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32075-1-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 32075-1-AP (same clone as 32075-1-PBS)

    IF Staining of THP-1 using 32075-1-AP (same clone as 32075-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using FRY antibody (32075-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 32075-1-PBS in a different storage buffer formulation.

FRY Polyclonal antibody, PBS Only

FRY Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 32075-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

C13orf14, FRY Microtubule Binding Protein, Protein furry homolog

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

32075-1-PBS targets FRY in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag34959

Product name: Recombinant human FRY protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 2534-2680 aa of NM_023037

Sequence: LEHSDLIMTLSPSEETNPMELLTTACDSTPAEPHSFNTRMSSFDASLPDMNNLQISEGSKAEAVREEEDTTVHEDDLSSSINELPAAFECSDSFSLDMTEGEEKGNRALDQFTLASFGEGDRGVSPPPSPFFSAILAAFQPAACDDA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 furry homolog (Drosophila)
别名 C13orf14, FRY Microtubule Binding Protein, Protein furry homolog
计算分子量339 kDa
观测分子量340 kDa
GenBank蛋白编号NM_023037
基因名称 FRY
Gene ID (NCBI) 10129
RRIDAB_3742522
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ5TBA9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The FRY gene encodes a protein involved in cell cycle regulation and DNA damage response. It plays a crucial role in the G2/M checkpoint, ensuring cells complete DNA repair before entering mitosis by activating the ATR-CHK1 signaling pathway. FRY is expressed in various tissues, including brain, liver, and testis, with notable expression in Sertoli and spermatogonial cells. Aberrant FRY function is associated with multiple diseases, such as cancer and neurodegenerative disorders. In cancer cells, FRY expression can influence proliferation and survival. Understanding FRY's role in cell cycle control and genome stability is vital for elucidating disease mechanisms and developing targeted therapies.

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