验证数据展示
产品信息
13448-1-AP targets FPR2 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IF, IHC |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 | FPR2 fusion protein Ag4282 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | formyl peptide receptor 2 |
| 别名 | ALXR, FMLP R I, FMLP R II, FMLP related receptor I, FMLPX, formyl peptide receptor 2, Formyl peptide receptor like 1, FPR2, FPR2A, FPRH1, FPRH2, FPRL1, HM63, Lipoxin A4 receptor, LXA4 receptor, LXA4R, N formyl peptide receptor 2, RFP |
| 计算分子量 | 351 aa, 39 kDa |
| GenBank蛋白编号 | BC029125 |
| 基因名称 | FPR2 |
| Gene ID (NCBI) | 2358 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P25090 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The formyl peptide receptors (FPRs) are a group of G protein-coupled chemoattractant receptorsthat play important roles in host defense and inflammation (PMID: 28335409). In humans, three different isoforms are expressed (FPR1, FPR2, and FPR3). FPR2, also known as FPRL1 or ALX, is expressed by many cell types including monocytes, neutrophils, macrophages, astrocytoma cells, epithelial cells. FPR2 conveys the biological functions of a variety of ligands, including N-formyl-methionyl peptides, the proresolution mediators annexin A1 (AnxA1) and lipoxin A4, as well as the activating and proinflammatory protein serum amyloid A (PMID: 22610094).
发表文章
| Species | Application | Title |
|---|---|---|
Cell Death Dis Amyloid-β(1-42) oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2. | ||
iScience SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury. | ||
Oncol Rep Formyl peptide receptor 2 expression predicts poor prognosis and promotes invasion and metastasis in epithelial ovarian cancer.
| ||
Hum Vaccin Immunother Exogenous murine antimicrobial peptide CRAMP significantly exacerbates Ovalbumin-induced airway inflammation but ameliorates oxazolone-induced intestinal colitis in BALB/c mice. |