验证数据展示
经过测试的应用
Positive FC detected in | HepG2 cells |
推荐稀释比
应用 | 推荐稀释比 |
---|---|
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
98383-2-RR targets FGFR4 in FC applications and shows reactivity with human samples.
经测试应用 | FC Application Description |
经测试反应性 | human |
免疫原 | Recombinant protein 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | fibroblast growth factor receptor 4 |
别名 | CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2 |
计算分子量 | 88 kDa |
GenBank蛋白编号 | BC011847 |
基因名称 | FGFR4 |
Gene ID (NCBI) | 2264 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P22455 |
储存缓冲液 | PBS with 0.09% sodium azide , pH 7.3 |
储存条件 | Store at 2 - 8°C. Stable for one year after shipment. |
背景介绍
Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501).
实验方案
Product Specific Protocols | |
---|---|
FC protocol for FGFR4 antibody 98383-2-RR | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |