Anti-Human FGFR4 Rabbit Recombinant Antibody

FGFR4 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98383-2-RR

产品说明书

CloneNo. 242713H4

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive FC detected inHepG2 cells

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98383-2-RR targets FGFR4 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 fibroblast growth factor receptor 4
别名 CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2
计算分子量 88 kDa
GenBank蛋白编号BC011847
基因名称 FGFR4
Gene ID (NCBI) 2264
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP22455
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501).

实验方案

Product Specific Protocols
FC protocol for FGFR4 antibody 98383-2-RRDownload protocol
Standard Protocols
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