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验证数据展示

  • IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

    IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11098-1-AP (FGFR4 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

    IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11098-1-AP (FGFR4 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 11098-1-AP (same clone as 11098-1-PBS)

    IF Staining of HepG2 using 11098-1-AP (same clone as 11098-1-PBS)

    Immunofluorescent analysis of (-20℃ Ethanol) fixed HepG2 cells using 11098-1-AP (FGFR4 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

  • WB analysis using 11098-1-AP (same clone as 11098-1-PBS)

    WB analysis using 11098-1-AP (same clone as 11098-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11098-1-AP (FGFR4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

FGFR4 Polyclonal antibody, PBS Only

FGFR4 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 11098-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

11098-1-PBS targets FGFR4 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag1573

Product name: Recombinant human FGFR4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 503-802 aa of BC011847

Sequence: KMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 fibroblast growth factor receptor 4
别名 CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2
计算分子量 88 kDa
观测分子量 95, 100-110 kDa
GenBank蛋白编号BC011847
基因名称 FGFR4
Gene ID (NCBI) 2264
RRIDAB_2103657
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP22455
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand-binding domains (PMID: 32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID: 20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID: 10336501).

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