验证数据展示
经过测试的应用
| Positive WB detected in | human kidney tissue, mouse spleen tissue, mouse kidney tissue, mouse small intestine tissue, rat kidney tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:8000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
31929-1-AP targets FCAMR/CD351 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag35303 Product name: Recombinant human FCAMR protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 17-170 aa of NM_001122979.2 Sequence: LPQKRPHPRWLWEGSLPSRTHLRAMGTLRPSSPLCWREESSFAAPNSLKGSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGSENNMLFLSMNLTI 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | Fc receptor, IgA, IgM, high affinity |
| 别名 | CD351, Fc Alpha And Mu Receptor, Fc alpha/mu receptor, FCA/MR, Fcalpha/MuR |
| 计算分子量 | 57 kDa |
| 观测分子量 | 60 kDa |
| GenBank蛋白编号 | NM_001122979.2 |
| 基因名称 | FCAMR |
| Gene ID (NCBI) | 83953 |
| RRID | AB_3670149 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q8WWV6 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
FCAMR, also known as CD351 or Fc α/µ receptor, is a type I transmembrane protein. Its extracellular region contains a short extracellular domain (EC) 1, an Ig variable (V) region-like EC2 domain and a stalk-like EC3 domain (PMID: 23182711). FCAMR is present in most B cells and macrophages and is a membrane surface protein that binds to the Fc fragment of IgA and IgM and induces endocytosis (PMID: 11779189). FCAMR may play a role in IgA- and IgM-mediated immune responses to microorganisms (PMID: 11062505).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for FCAMR/CD351 antibody 31929-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
