验证数据展示
产品信息
32472-1-PBS targets FAM86A in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag38481 Product name: Recombinant human FAM86A protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-330 aa of BC010084 Sequence: MAPEENAGTELLLQSFERRFLAARTLRSFPWQSLEAKLRDSSDSELLRDILHKTVKHPVCVKHPPSVKYARCFLSELIKKHEAVHTEPLDELYEALAETLMAKESTQGHRSYLLPSGGSVTLSESTAIISYGTTGLVTWDAALYLAEWAIENPAVFTNRTVLELGSGAGLTGLAICKMCRPRAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAKLDSPRVTVAQLDWDVATVHQLSAFQPDVVIAADVLYCPEAIMSLVGVLRRLAACREDQRAPEVYVAFTVRNPETCQLFTTELGRAGIRWEVEPRHEQKLFPYEEHLEMAMLNLTL 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | family with sequence similarity 86, member A |
| 别名 | EC:2.1.1.-, EEF2KMT, eEF2-KMT, eEF2-lysine methyltransferase, Eukaryotic Elongation Factor 2 Lysine Methyltransferase |
| 观测分子量 | 38 kDa |
| GenBank蛋白编号 | BC010084 |
| 基因名称 | FAM86A |
| Gene ID (NCBI) | 196483 |
| RRID | AB_3742623 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q96G04 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
FAM86A is a class I lysine methyltransferase (KMT), belonging to the family of protein methyltransferases (KMTs), which produces trimethylation (K525me3) at the Lys525 site of eukaryotic translation elongation factor 2 (EEF2) and promotes the binding of eEF2 to ribosomes, thereby regulating the protein synthesis. (PMID: 38508183) FAM86A is expressed in a highly dependent manner in a variety of human cancer cell lines, suggesting that FAM86A may be a potential target for future anticancer therapy.
