验证数据展示
产品信息
67167-1-PBS targets FABP4 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig samples.
| 经测试应用 | WB, IHC, Indirect ELISA Application Description |
| 经测试反应性 | Human, mouse, rat, pig |
| 免疫原 | FABP4 fusion protein Ag8565 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | fatty acid binding protein 4, adipocyte |
| 别名 | A FABP, AFABP, ALBP, aP2, FABP4, Fatty acid binding protein 4 |
| 计算分子量 | 132 aa, 15 kDa |
| 观测分子量 | 14 kDa |
| GenBank蛋白编号 | BC003672 |
| 基因名称 | FABP4 |
| Gene ID (NCBI) | 2167 |
| RRID | AB_2882463 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P15090 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Fatty acid binding protein (FABP) 4 is a member of the FABP family which abundantly expressed, fatty acid carrier proteins. FABPs are capable of binding a variety of hydrophobic molecules such as long-chain fatty acids and are important for their uptake and intracellular trafficking. It was first identified as an adipocyte-specific protein, important for the maintenance of lipid and glucose metabolism. It is also detected in macrophages, where it participates in regulating inflammation and cholesterol trafficking via NFκB and PPAR. In more recent studies, FABP4 has been found in a variety of endothelial cells, where it has been identified as a target of VEGF and a regulator of cell proliferation and possibly angiogenesis. Pathologically, FABP4 has been associated with the development of metabolic syndrome, diabetes and cancer and vulnerability of atherosclerotic plaques. FABP4 has been identified as a novel prognostic factor for both adverse cardiovascular events and breast cancer.