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验证数据展示

  • WB analysis of mouse liver using 20963-1-AP (same clone as 20963-1-PBS)

    WB analysis of mouse liver using 20963-1-AP (same clone as 20963-1-PBS)

    mouse liver tissue were subjected to SDS PAGE followed by western blot with 20963-1-AP (F5 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20963-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 20963-1-AP (same clone as 20963-1-PBS)

    IHC staining of human liver cancer using 20963-1-AP (same clone as 20963-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 20963-1-AP (F5 Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20963-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 20963-1-AP (same clone as 20963-1-PBS)

    IHC staining of human liver cancer using 20963-1-AP (same clone as 20963-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 20963-1-AP (F5 Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20963-1-PBS in a different storage buffer formulation.

Factor V Polyclonal antibody, PBS Only

Factor V Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20963-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

F5, Coagulation factor V heavy chain, Coagulation factor V light chain, FVL, PCCF

缓冲液配方: 
偶联物:  Unconjugated
规格价格库存

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产品信息

20963-1-PBS targets Factor V in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 coagulation factor V (proaccelerin, labile factor)
别名 F5, Coagulation factor V heavy chain, Coagulation factor V light chain, FVL, PCCF
计算分子量 252 kDa
观测分子量 145 kDa
GenBank蛋白编号NM_000130
基因名称 F5
Gene ID (NCBI) 2153
RRIDAB_2878773
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP12259
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

There are 13 blood coagulation factors found in the blood. There are 13 blood coagulation factors found in the blood. F5 has little or no intrinsic procoagulant activity prior to its activation through limited proteolysis by thrombin or F10a at Arg709, Arg1018 and Arg1545. The resulting F5a molecule is a heterodimer that consists of a 105 kDa heavy chain and a 71/74 kDa light chain that are noncovalently associated in a calcium-dependent manner. The intact procofactor molecule (330 kDa) as well as proteins similar in size to the factor Va light chain (74 kDa) and both light chain precursors (280 and 220 kDa) found in factor Va(IIa) were observed. And factor Xa cleaves the factor Va light chain at Arg1765 into fragments of ~30 and ~48 kDa (residues 1546-1765 and 1766-2196, respectively) in the bovine and human systems.

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