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验证数据展示

  • IHC staining of human skin cancer using 66099-1-Ig (same clone as 66099-1-PBS)

    IHC staining of human skin cancer using 66099-1-Ig (same clone as 66099-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skin cancer slide using 66099-1-Ig (EXOSC2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66099-1-Ig (same clone as 66099-1-PBS)

    IHC staining of human liver using 66099-1-Ig (same clone as 66099-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver slide using 66099-1-Ig (EXOSC2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 66099-1-Ig (same clone as 66099-1-PBS)

    IF Staining of HepG2 using 66099-1-Ig (same clone as 66099-1-PBS)

    Immunofluorescent analysis of () fixed HepG2 cells using 66099-1-Ig (EXOSC2 antibody) at dilution of 1:25. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

  • WB analysis using 66099-1-Ig (same clone as 66099-1-PBS)

    WB analysis using 66099-1-Ig (same clone as 66099-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66099-1-Ig (EXOSC2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Alpha Tubulin Monoclonal antibody (HRP-66031) as loading control. This data was developed using the same antibody clone with 66099-1-PBS in a different storage buffer formulation.

EXOSC2 Monoclonal antibody, PBS Only

EXOSC2 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 66099-1-PBS

产品说明书

CloneNo. 1G8B1

宿主/亚型

Mouse / IgG2a

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66099-1-PBS targets EXOSC2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原 EXOSC2 fusion protein Ag7003 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 exosome component 2
别名 EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p
计算分子量 33 kDa
观测分子量 33 kDa
GenBank蛋白编号BC000747
基因名称 EXOSC2
Gene ID (NCBI) 23404
RRIDAB_2881498
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ13868
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs [PMID:15346807]. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events [PMID: 17545563].