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验证数据展示

  • WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

    WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 23525-1-AP (ESCO2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

  • WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

    WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 23525-1-AP (ESCO2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 23525-1-AP (same clone as 23525-1-PBS)

    IHC staining of human skin cancer using 23525-1-AP (same clone as 23525-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 23525-1-AP (ESCO2 antibody) at dilution of 1:300 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

ESCO2 Polyclonal antibody, PBS Only

ESCO2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 23525-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

N acetyltransferase ESCO2, hEFO2, Establishment factor-like protein 2, EFO2p, EFO2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

23525-1-PBS targets ESCO2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag18893

Product name: Recombinant human ESCO2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-353 aa of BC146562

Sequence: MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFM

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 establishment of cohesion 1 homolog 2 (S. cerevisiae)
别名 N acetyltransferase ESCO2, hEFO2, Establishment factor-like protein 2, EFO2p, EFO2
计算分子量 601 aa, 68 kDa
观测分子量 65-70 kDa
GenBank蛋白编号BC146562
基因名称 ESCO2
Gene ID (NCBI) 157570
RRIDAB_2879292
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen Affinity purified
UNIPROT IDQ56NI9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ESCO2 is also known as Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2, EFO2. This gene encodes a member of the family of acetyltransferases involved in the establishment of sister chromatid cohesion during S phase and postreplicative sister chromatid cohesion induced by double-strand breaks (PubMed: 15821733). Mutations in the ESCO2 gene are associated with a rare genetic disorder called Roberts syndrome or SC phocomelia syndrome (PubMed: 16380922). The loss of function or impaired activity of the ESCO2 protein due to mutations disrupts the proper cohesion of sister chromatids, leading to chromosomal abnormalities and the characteristic features of Roberts syndrome. ESCO2 can be detected as about 65-70 kDa.

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