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验证数据展示

  • WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)

    WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

    IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

    IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

ERLIN2 Polyclonal antibody, PBS Only

ERLIN2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 14781-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14781-1-PBS targets ERLIN2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag6369

Product name: Recombinant human ERLIN2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 23-206 aa of BC067765

Sequence: VHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQGVMVTYGQEMLKNLVLRSWSQRSSWRMLIAMQQDP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ER lipid raft associated 2
别名
计算分子量 38 kDa
观测分子量 38-45 kDa
GenBank蛋白编号BC067765
基因名称 ERLIN2
Gene ID (NCBI) 11160
RRIDAB_2098859
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO94905
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.

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