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验证数据展示

  • WB analysis of mouse brain using 19943-1-AP (same clone as 19943-1-PBS)

    WB analysis of mouse brain using 19943-1-AP (same clone as 19943-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 19943-1-AP (ERBB4 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19943-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse heart using 19943-1-AP (same clone as 19943-1-PBS)

    IF Staining of mouse heart using 19943-1-AP (same clone as 19943-1-PBS)

    Frozen tissue section of embryonic mouse heart (E12.5) was stained for cardiac troponin-T/cTnT (green) and ErbB4 (red, Cat. No 19943-1-AP) with DAPI as a counterstain for visualizing the nucleus (blue). cTnT stains cardiomyocytes and was visualized with an Alexa Fluor 488 secondary antibody. ErbB4 is a key member of ErbB signaling and involved in development and was visualized with an Alexa Fluor 555 secondary antibody. The Image and figure legends are intellectual property of @LAF_in_the_LAB. This data was developed using the same antibody clone with 19943-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 19943-1-AP (same clone as 19943-1-PBS)

    IHC staining of human kidney using 19943-1-AP (same clone as 19943-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 19943-1-AP (ERBB4 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 19943-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse lung using 19943-1-AP (same clone as 19943-1-PBS)

    IHC staining of mouse lung using 19943-1-AP (same clone as 19943-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 19943-1-AP (ERBB4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19943-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse lung using 19943-1-AP (same clone as 19943-1-PBS)

    IHC staining of mouse lung using 19943-1-AP (same clone as 19943-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 19943-1-AP (ERBB4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19943-1-PBS in a different storage buffer formulation.

ERBB4 Polyclonal antibody, PBS Only

ERBB4 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 19943-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

4ICD, E4ICD, EC:2.7.10.1, ERBB4 intracellular domain, HER4

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

19943-1-PBS targets ERBB4 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
别名 4ICD, E4ICD, EC:2.7.10.1, ERBB4 intracellular domain, HER4
计算分子量 147 kDa
观测分子量 180 kDa, 147 kDa
GenBank蛋白编号NM_001042599
基因名称 ERBB4
Gene ID (NCBI) 2066
RRIDAB_10646486
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ15303
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ERBB4, also named p180erbB4 and HER4, belongs to the protein kinase superfamily, Tyr protein kinase family, and EGF receptor subfamily. ERBB4 specifically binds and it is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin, and NTAK. Interaction with these factors induces cell differentiation. ERBB4 is not activated by EGF, TGF-A, and amphiregulin. ERBB4 catalyzes the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. The antibody recognizes the C-term of ERBB4. Alternatively spliced variants that encode different protein isoforms with a calculated molecular weight of 144-147 kDa have been described. The apparent molecular weight of full-length ERBB4 is 150-200 kDa due to glycosylation and phosphorylation. Full-length ERBB4 can be cleaved into an 80-kDa ERBB4 intracellular fragment and a 120-kDa extracellular fragment (PMID: 11343971; 16251361).

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