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验证数据展示

  • WB analysis using 84608-5-RR (same clone as 84608-5-PBS)

    WB analysis using 84608-5-RR (same clone as 84608-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84608-5-RR (EMR2/CD312 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84608-5-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 84608-5-RR (same clone as 84608-5-PBS)

    IF Staining of THP-1 using 84608-5-RR (same clone as 84608-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using EMR2/CD312 antibody (84608-5-RR, Clone: 242042E3 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84608-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84608-5-RR

    Affinity and Kinetic Characterization of 84608-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84608-5-RR against Human EMR2 were performed. The affinity constant is 1.45 nM.

EMR2/CD312 Recombinant monoclonal antibody, PBS Only

EMR2/CD312 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 84608-5-PBS

产品说明书

CloneNo. 242042E3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

EMR2, 242042E3, ADGRE2, Adhesion G protein-coupled receptor E2, CD312

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84608-5-PBS targets EMR2/CD312 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg2479

Product name: Recombinant Human EMR2 protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 24-260 aa of NM_013447.3

Sequence: QDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITTPMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 egf-like module containing, mucin-like, hormone receptor-like 2
别名 EMR2, 242042E3, ADGRE2, Adhesion G protein-coupled receptor E2, CD312
计算分子量90 kDa
观测分子量75~90 kDa
GenBank蛋白编号NM_013447.3
基因名称 EMR2
Gene ID (NCBI) 30817
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ9UHX3-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

EMR2 (Epidermal Growth Factor-like module-containing Mucin-like Hormone Receptor 2), also known as ADGRE2, is a member of the adhesion-GPCR family that contains extracellular EGF-like domains. EMR2 contains a total of five tandem EGF-like domains and expresses similar protein isoforms consisting of various numbers of EGF-like domains as a result of alternative RNA splicing (PMID: 10903844). EMR2 is restricted to myeloid cells including monocytes, macrophages, dendritic cells and granulocytes28 and its expression is highly regulated during monocyte/macrophage differentiation (PMID: 31969668).The ligation of EMR2 could increase neutrophil adhesion, migration and anti-microbial mediator production and could enhance the systemic inflammation (PMID: 27905560).

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