验证数据展示
产品信息
68171-1-PBS targets EIF4E3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat, mouse samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | human, rat, mouse |
免疫原 | EIF4E3 fusion protein Ag11056 种属同源性预测 |
宿主/亚型 | Mouse / IgG2b |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | eukaryotic translation initiation factor 4E family member 3 |
别名 | eIF 4E type 3, eIF 4E3, eIF4E 3, eIF4E type 3, EIF4E3 |
计算分子量 | 24 kDa |
观测分子量 | 24-30 kDa |
GenBank蛋白编号 | BC031289 |
基因名称 | EIF4E3 |
Gene ID (NCBI) | 317649 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q8N5X7 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
EIF4E3, also known as Eukaryotic translation initiation factor 4E type 3, is a 224 amino acid protein, which recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. EIF4E3 acts as a tissue-specific tumor suppressor. For instance, eIF4E3 inhibits expression of both mRNA export and translation targets of eIF4E1, consistent with its nuclear and cytoplasmic localization. Importantly, eIF4E3 overexpression represses oncogenic transformation. (PMID: 23587918).