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验证数据展示

  • WB analysis using 27944-1-AP (same clone as 27944-1-PBS)

    WB analysis using 27944-1-AP (same clone as 27944-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27944-1-AP (EIF2AK4 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27944-1-PBS in a different storage buffer formulation.

  • IHC staining of human small intestine using 27944-1-AP (same clone as 27944-1-PBS)

    IHC staining of human small intestine using 27944-1-AP (same clone as 27944-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 27944-1-AP (EIF2AK4 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 27944-1-PBS in a different storage buffer formulation.

  • IHC staining of human small intestine using 27944-1-AP (same clone as 27944-1-PBS)

    IHC staining of human small intestine using 27944-1-AP (same clone as 27944-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 27944-1-AP (EIF2AK4 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 27944-1-PBS in a different storage buffer formulation.

EIF2AK4 Polyclonal antibody, PBS Only

EIF2AK4 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27944-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

EC:2.7.11.1, eIF-2-alpha kinase GCN2, Eukaryotic translation initiation factor 2-alpha kinase 4, GCN2, GCN2 like protein

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27944-1-PBS targets EIF2AK4 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag27617

Product name: Recombinant human EIF2AK4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 875-1080 aa of BC009350

Sequence: AFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 eukaryotic translation initiation factor 2 alpha kinase 4
别名 EC:2.7.11.1, eIF-2-alpha kinase GCN2, Eukaryotic translation initiation factor 2-alpha kinase 4, GCN2, GCN2 like protein
计算分子量 187 kDa
观测分子量~200 kDa
GenBank蛋白编号BC009350
基因名称 EIF2AK4
Gene ID (NCBI) 440275
RRIDAB_3669630
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9P2K8
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

EIF2AK4 (eukaryotic translation initiation factor 2 α kinase 4), formerly known as GCN2, a member of serine/threonine kinases, is comprised of an N-terminal RWD domain (20-137) involved in protein-protein interactions, pseudokinase (276-539) and kinase domains (585-1016) and C-terminal domain (1533-1649) where binding to ribosomes and recognition of uncharged tRNAs occur. It downregulates protein synthesis in response to a variety of cellular stress such as hypoxia, viral infection, and amino acid deprivation (PMID: 38776952, 26300654). Mutant EIF2AK4 could promote proliferation of small pulmonary arteries by crosstalk with mammalian targets of the rapamycin signaling pathway (PMID: 24135949).

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