验证数据展示
产品信息
15568-1-PBS targets DUSP26 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag7831 Product name: Recombinant human DUSP26 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-211 aa of BC001613 Sequence: MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | dual specificity phosphatase 26 (putative) |
| 别名 | DSP 4, DSP-4, DUSP24, EC:3.1.3.16, LDP 4 |
| 计算分子量 | 24 kDa |
| 观测分子量 | 20~24 kDa |
| GenBank蛋白编号 | BC001613 |
| 基因名称 | DUSP26 |
| Gene ID (NCBI) | 78986 |
| RRID | AB_3741867 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9BV47 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Dual specificity phosphatase 26 (DUSP26) is an atypical DUSP with a range of physiological substrates including the MAPKs. DUSP26 is highly expressed in neuro-endocrine tissue and is absent in several human cancer cell lines including those derived from brain tumours, neuroblastomas, squamous tumours, lymphoma, colon cancer, non-small cell lung cancer, melanoma, prostatic carcinoma, breast carcinoma and cervical carcinoma (PMID: 33466673, 39222869). DUSP26 exerts a cytoprotective role by selectively dephosphorylating p53 at serine 312. DUSP26 is a 24kda atypical type Ⅰ cysteine-based dual-specificity phosphatase (PMID: 41748589, 35313355).
