验证数据展示
产品信息
10172-2-AP targets DUSP14 in ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag0228 Product name: Recombinant human DUSP14 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-198 aa of BC004448 Sequence: MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | dual specificity phosphatase 14 |
| 别名 | DUSP14, MAP kinase phosphatase 6, MKP 6, MKP L, MKP6 |
| 计算分子量 | 22 kDa |
| GenBank蛋白编号 | BC004448 |
| 基因名称 | DUSP14 |
| Gene ID (NCBI) | 11072 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O95147 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulator receptor, such as CD28. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14/ MAP kinase phosphatase-6 (MKP6) is a negative regulator of CD28
