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验证数据展示

  • WB analysis using 84053-6-RR (same clone as 84053-6-PBS)

    WB analysis using 84053-6-RR (same clone as 84053-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84053-6-RR (DSG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

  • IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84053-6-RR (DSG1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DSG1 antibody included
  • IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    IHC staining of mouse skin using 84053-6-RR (same clone as 84053-6-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84053-6-RR (DSG1 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84053-6-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DSG1 antibody included
  • Affinity and Kinetic Characterization of 84053-6-RR

    Affinity and Kinetic Characterization of 84053-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84053-6-RR against Human DSG1 were performed. The affinity constant is 71.2 pM.

    {{ptg:ProductFeaturesInfo}}

DSG1 Recombinant monoclonal antibody, PBS Only

DSG1 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84053-6-PBS

产品说明书

CloneNo. 241093G11

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, IHC, Indirect ELISA

别名

Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy DSG1 Ready-To-Use IHC Kit. DSG1 primary antibody included.

产品信息

84053-6-PBS targets DSG1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag20184

Product name: Recombinant human DSG1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 756-1049 aa of BC153001

Sequence: KKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 desmoglein 1
别名 Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4
计算分子量 1049 aa, 114 kDa
观测分子量160 kDa
GenBank蛋白编号BC153001
基因名称 DSG1
Gene ID (NCBI) 1828
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ02413
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG1 is a single-pass transmembrane glycoprotein highly expressed in the epidermis and localized primarily within the suprabasal epithelial layers (PMID: 16286477; 24220297). DSG1 mediates intercellular adhesion and is crucial in maintaining epidermal integrity and barrier function (PMID: 23974871). It is also involved in epithelial cell differentiation (PMID: 23524961). Mutations in the DSG1 gene can cause the autosomal dominant disorder to striate palmoplantar keratoderma and a syndrome featuring severe dermatitis, multiple allergies, and metabolic wasting (SAM syndrome) (PMID: 29315490; 23974871).