验证数据展示
产品信息
27243-1-PBS targets DSCR3 in IP, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | IP, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag23350 Product name: Recombinant human DSCR3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-297 aa of BC110655 Sequence: MGTALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHPDHLITENFPLKLCRI 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | Down syndrome critical region gene 3 |
| 别名 | DCRA, DSCRA |
| 观测分子量 | 30-33 kDa |
| GenBank蛋白编号 | BC110655 |
| 基因名称 | DSCR3 |
| Gene ID (NCBI) | 10311 |
| RRID | AB_3742221 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O14972 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
DSCR3 (Down syndrome critical region protein 3) encodes VPS26C (Vacuolar protein sorting-associated protein 26C), a member of the retriever integral membrane protein recycling pathway. DSCR3 is a component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PMID: 31845315). DSCR3 specifically facilitates the transport of LRP1, but not of LDLR, from the endosomes to the plasma membrane, and hereby controls postprandial TG levels in plasma (PMID: 36353989, 35187626).
