验证数据展示
产品信息
32634-1-PBS targets DSCAML1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag36336 Product name: Recombinant human DSCAML1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1879-2053 aa of NM_020693 Sequence: ADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | Down syndrome cell adhesion molecule like 1 |
| 别名 | Cell adhesion molecule DSCAML1, Down syndrome cell adhesion molecule 2, Down syndrome cell adhesion molecule-like protein 1, DSCAM2, KIAA1132 |
| 计算分子量 | 224 kDa |
| 观测分子量 | 224 kDa |
| GenBank蛋白编号 | NM_020693 |
| 基因名称 | DSCAML1 |
| Gene ID (NCBI) | 57453 |
| RRID | AB_3742686 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q8TD84 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Down syndrome cell adhesion molecule-like protein 1 (DSCAML1) is a transmembrane protein with ten immunoglobulin (Ig) and six fibronectin type III domains (PMID: 11453658). It is involved in neuronal cell adhesion and plays a crucial role in the development and function of the nervous system. DSCAML1 has been shown to participate in neuronal tiling, avoidance of neurite fasciculation, and axon guidance (PMID: 18216855; 21029858). Additionally, DSCAML1 is required for the proper placement of GABAergic neurons in the entorhinal cortex (ECx) and suppression of seizure susceptibility in rodents (PMID: 33256836).
