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验证数据展示

  • WB analysis using 86433-8-RR (same clone as 86433-8-PBS)

    WB analysis using 86433-8-RR (same clone as 86433-8-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86433-8-RR (Claudin 4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86433-8-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 86433-8-RR (same clone as 86433-8-PBS)

    IHC staining of human colon using 86433-8-RR (same clone as 86433-8-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 86433-8-RR (Claudin 4 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86433-8-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 86433-8-RR (same clone as 86433-8-PBS)

    IHC staining of human colon using 86433-8-RR (same clone as 86433-8-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 86433-8-RR (Claudin 4 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86433-8-PBS in a different storage buffer formulation.

Claudin 4 Recombinant monoclonal antibody, PBS Only

Claudin 4 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 86433-8-PBS

产品说明书

CloneNo. 251202E6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

CLDN4, CPE R, CPE receptor, CPER, CPE-R

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86433-8-PBS targets Claudin 4 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 claudin 4
别名 CLDN4, CPE R, CPE receptor, CPER, CPE-R
计算分子量 22 kDa
观测分子量18-20 kDa
GenBank蛋白编号BC000671
基因名称 Claudin 4
Gene ID (NCBI) 1364
RRIDAB_3744879
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO14493
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Claudins are a family of proteins that are the most important components of tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They are small (20-27 kDa) proteins with similar structures. They have four transmembrane domains, with the N- and C-termini in the cytoplasm. This antibody is specifically against Claudin 4. Claudin 4 is overexpressed in a variety of cancers. It can be used as a predictor of recurrent malignant pleural effusion in patients with advanced non-small cell lung cancer (PMID: 38629624). Claudin 4 is the receptor for B. fragilis toxin (BFT), an important oncogenic protein. Blocking the interaction between BFT and Claudin-4 can inhibit the cleavage of the substrate E-cadherin by BFT and reverse the tissue damage induced by BFT in mice (PMID: 42020735).

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