验证数据展示
产品信息
98681-1-PBS targets Claudin 19 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | claudin 19 |
| 别名 | Claudin-19, CLDN19 |
| 计算分子量 | 23 kDa |
| GenBank蛋白编号 | BC030524 |
| 基因名称 | CLDN19 |
| Gene ID (NCBI) | 149461 |
| RRID | AB_3746269 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8N6F1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Claudin-19 is a critical transmembrane protein and belongs to the claudin family, which are the primary structural and functional components of tight junctions (TJs) in epithelial and endothelial cell sheets. Mutations in the CLDN19 are primarily associated with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC) with severe ocular involvement (PMID: 17389678). In breast cancer, Claudin-19 expression is frequently lost or downregulated, which correlates with poor patient prognosis (PMID: 15883201, 37344378).
