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验证数据展示

  • WB analysis of Jurkat using 85104-3-RR (same clone as 85104-3-PBS)

    WB analysis of Jurkat using 85104-3-RR (same clone as 85104-3-PBS)

    Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with 85104-3-RR (Cleaved Caspase 10/P23 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85104-3-PBS in a different storage buffer formulation.

Cleaved Caspase 10/P23 Recombinant antibody, PBS Only

Cleaved Caspase 10/P23 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85104-3-PBS

产品说明书

CloneNo. 242468G11

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

CASP10, Caspase10, 242468G11, Apoptotic protease Mch 4, Apoptotic protease Mch-4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85104-3-PBS targets Cleaved Caspase 10/P23 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 caspase 10, apoptosis-related cysteine peptidase
别名 CASP10, Caspase10, 242468G11, Apoptotic protease Mch 4, Apoptotic protease Mch-4
计算分子量 59 kDa
观测分子量23 kDa
GenBank蛋白编号BC042844
基因名称 Caspase 10
Gene ID (NCBI) 843
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ92851
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). This antibody recognize the cleaved caspase 10.