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Recombinant Canine MCP-1/CCL2 protein (rFc Tag)

种属

Canine

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg4550

Print datasheet

Synonyms

CCL2, MCP-1, C-C motif chemokine 2, MCP1

验证数据展示

  • Purity of Recombinant Canine MCP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Canine MCP-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Canine MCP-1 protein Gln24-Pro101 (Accession# P52203) with a rabbit IgG Fc tag at the C-terminus.
基因ID 403981
蛋白编号 P52203
预测分子量 35.1 kDa
SDS-PAGE 36-45 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

MCP-1 (also known as CCL2) is a member of the chemokine family. MCP-1 recruits monocytes, memory T cells and dendritic cells to sites of inflammation caused by either tissue injury or infection. MCP-1 has been implicated in the pathogenesis of diseases characterised by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. It binds to the chemokine receptors CCR2 and CCR4. Increased expression of MCP-1 is associated with severe acute respiratory syndrome coronavirus 2 infection.

参考文献:

1.Singh S. et al. (2021) Int Immunopharmacol. 101(Pt B):107598. 
2.Lin Z. et al. (2023) Front Immunol. 13:1053457.
3.Li X. et al. (2017) Gut. 6(1):157-167.
4.Huang B. et al. (2007) Cancer Lett. 252(1):86-92.